Test Details: Mitochondria Encephalopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) is maternally inherited disorder characterised by stroke like episodes, encephalopathy with seizures and/or dementia and mitochondrial myopathy with multisystem involvement. The A3243G mutation in the t RNA leu (MTTL1) gene of mitochondrial DNA accounts for about 80% of MELAS cases and the remaining cases involve other point mutations.