Test Details: Hereditary Breast and Ovarian Cancer (HBOC) is an inherited genetic condition. A diagnosis of HBOC is considered when there are multiple cases of breast cancer and/or ovarian cancer on the same side of the family. There are 2 primary genes linked with most families who have HBOC: BRCA1 and BRCA2. There are also other genes that have been linked with an increased risk of developing breast and other cancers, such as mutations in the TP53 and PALB2. This test helps in detection of variants in the BRCA1 , BRCA2, TP53 and PALB2 genes.